Winding Up the Internal Circadian Clock and Preterm Ductus

The circadian system regulates many aspects of physiological functions in human body and requires a delicate interplay between suprachiasmatic nucleus, pineal gland, melatonin and clock genes. Maturation and synchronization of the fetal circadian system is mostly governed by maternal master clock and needs a complete and uncomplicated intrauterine life. Premature birth is being born not only with underdeveloped organ systems, but also with deprivation of this preparation period. Currently there is no proven association between ductal closure and circadian system, however there are clues that clock genes can affect vascular morphogenesis and function. With better understanding the cyclic environment in utero, we can have an opportunity to modify our current strategies in neonatal care. Preterm ductus may really have an internal clock that needs to be wounded in order to be properly programmed for closing.